Coeptis Therapeutics Shares Rally 67% In May, Clinical Interests And Planned Acquisitions Attract The Interest ($COEP)

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Coeptis Therapeutics Shares Rally 67% In May, Clinical Interests And Planned Acquisitions Attract The Interest ($COEP)

May 30
05:25 2023
Coeptis Therapeutics Shares Rally 67% In May, Clinical Interests And Planned Acquisitions Attract The Interest ($COEP)

The over 67% share price rally in Coeptis Therapeutics (NasdaqGM: COEP) during May may have more room to run. In fact, at $1.98 at the close last Friday, COEP shares appear on track to attack its recent intraday high of $2.19, a level not seen since November 2022. Investors have reasons to be bullish. Foremost is that COEP has been striking deals and providing proof that supports its ambitions of developing innovative cell therapy platforms for cancer that have the potential to disrupt conventional treatment paradigms and improve patient outcomes.

Most recently, COEP announced that research involving its SNAP-CAR technology was detailed in a peer-reviewed article in Nature Communications. SNAP-CAR is a multi-antigen chimeric antigen receptor T cell (CAR T) technology that can be adapted to different cancer indications, including hematologic and solid tumors. More specifically, the coverage described key advances in antigen receptor design that can be instrumental in developing “universal” receptor systems for diverse programming of cell behaviors using covalent chemistry. Further, it was concluded that these systems have the potential for clinical application and biotechnological utility by allowing researchers to rapidly screen CAR and synNotch antibody candidates and rewire and activate cellular programs in response to particular antibody-antigen interactions.

Of course, helping pioneer advances in the bio-pharmaceutical space does come with perks. One of them is earning the attention of its peers, which it did, evidenced by the peer-reviewed publication. But another one, perhaps more valuable, is gaining the attention of investors. Recent share price trajectory shows they achieved that reach as well. Deservedly so on both. But, the value proposition in COEP isn’t built on a single headline. Instead, they have been publishing plenty of supporting evidence to indicate that intentions for 2023 are to grow bigger faster.

Value Drivers Are Gaining Strength

The publication in Nature Communications deserves more attention since it identifies what can drive COEP programs forward. Notably, it highlighted research showing key advances in antigen receptor design, including creating a universal adaptor synNotch system and a universal CAR system that acts through self-labeling enzyme chemistry. That’s more than an important measure; it’s a potential breakthrough in programmable antigen targeting. Why is that important?

Because research indicates and supports that these ‘universal’ receptor systems, where receptor specificity can be directed post-translationally through covalent attachment of a co-administered antibody, potentially allow for one population of T cells to target multiple tumor antigens. That enables the development of cell therapies for a wide range of cancers, including hematologic and solid tumors. Furthermore, it supports the thesis that SNAP-CAR can be a powerful technology holding the potential to be engineered to address other cancers, including HER2-expressing cancer, which COEP is targeting as its potential first-in-human clinical development program. There’s more driving the value proposition.

In April, COEP announced entering a binding term sheet with Deverra Therapeutics, Inc. That agreement provides exclusivity until August 31, 2023, to negotiate toward acquiring or licensing assets from Deverra Therapeutics, specifically those related to its proprietary allogeneic stem cell expansion and directed differentiation platform for the generation of multiple distinct immune effector cell types, including natural killer (NK) and monocyte/macrophages.

The transaction, if finalized, would provide Coeptis with, among other assets, exclusive rights to two FDA-approved Investigational New Drug (IND) applications and two Phase 1 clinical trials (NCT04901416, NCT04900454) investigating infusion of DVX201, an unmodified natural killer (NK) cell therapy generated from pooled donor CD34+ cells, in hematologic malignancies and viral infections. In addition, Coeptis would gain access to a highly scalable allogeneic cellular immunotherapy platform that is being developed to generate and deliver off-the-shelf (no HLA matching), cost-effective, on-demand cell therapies to a broad patient population. Deverra expects phase I clinical trial data from its AML study to be complete during 2H 2023.

Strengthening And Diversifying Its Clinical Pipeline Ambitions

The better news is this: According to its release, the finalized transaction would significantly expand and enhance Coeptis’ technology portfolio with a cutting-edge allogeneic cell therapy platform with extensive safety and clinical data that would also enable aligning its development ambitions with leading cell and gene therapy experts. That’s not all. Investors appreciate diversification, and this deal checks that box. COEP noted that adding these clinical and pre-clinical immune effector cell programs would significantly diversify its R&D capabilities and strengthen clinical pipeline assets with multiple novel approaches to combination cellular immunotherapy not yet achieved by others.

Additionally, the inherent capabilities of the allogeneic cell therapy platform could open new pathways for Coeptis to expand its cell-based therapies beyond autologous CAR T. In fact, COEP management noted in its release that they are “excited about the possibility of exploring the application of both the SNAP-CAR and GEAR technologies to allogeneic, off-the-shelf immune effector cells. The NK and macrophage (MAC) immune effector cell generation from Deverra’s platform combined with Coeptis’ target specific CARs has the potential to result in development of allogeneic NK and MAC cell therapies.” The excitement is warranted.

Deverra’s allogeneic cell therapy platform has been used clinically since 2006, with substantial and promising clinical and safety data recorded. While that’s valuable, so is the platform showing the capability to provide extreme flexibility and optionality in generating and modifying multiple distinct immune effector cell types from a single platform. Both companies believe this bringing together their established platforms could generate first-in-class allogeneic cell therapies to treat a wide range of life-threatening disorders in a cost-effective and clinically accessible way. Indeed, that’s a potentially massive value driver and a potentially near-term one at that.

There’s still more to like.

Working Partnerships To Advance Needed Therapeutics

Coeptis is advancing additional programs with other companies, including Deverra, evaluating an allogeneic stem cell platform and DVX201, an unmodified natural killer (NK) cell therapy in Phase 1 clinical trials, a universal, multi-antigen CAR T technology licensed from the University of Pittsburgh (SNAP-CAR), and intellectual property and know-how related to the GEAR™ cell therapy and companion diagnostic platforms, which Coeptis is developing with VyGen-Bio and leading medical researchers at the Karolinska Institutet.

The science can be complicated, but the strategy isn’t. Coeptis’ business model is designed around maximizing the value of its current product portfolio and rights through in-license agreements, out-license agreements, and co-development relationships, as well as entering into strategic partnerships to expand its product rights and offerings, specifically those targeting cancer. In other words, COEP is putting in play multiple shots on goal to bring better therapeutics to market and create what could be enormous shareholder value.

Part of that can come through the exclusive option agreements with VyGen-Bio, Inc., involving technologies designed to improve the treatment of CD38-related cancers. For its part, Coeptis will assist VyGen-Bio in its efforts to develop and commercialize CD38-GEAR-NK, a pre-clinical in vitro proof of concept product designed to protect CD38+ NK cells from destruction by antiCD38 mAbs. They will also contribute to developing a CD38-Diagnostic, a discovery-stage product intended to analyze if cancer patients might be appropriate candidates for anti-CD38 mAb therapy.

There’s another value driver. Coeptis currently has a 50% (which could scale down to 25%) revenue stream interest and co-development rights for CD38-GEAR-NK and a 50% revenue stream interest related to CD38-Diagnostic from VyGen-Bio. Coeptis is entitled to receive future revenue from both products.

Multiple Shots On Revenue-Generating Goals

Indeed, COEP is far from a one-dimensional, single-shot-on-goal biotech company. In fact, despite its smallcap price, this company is advancing some big-time programs that can change the revenue-generating trajectory considerably in the coming quarters. Remember, COEP is developing some novel things, so licensing and partnerships, with cash upfront, is certainly an opportunity that should be recognized.

And know this too. Coeptis’ cell and gene therapies are more than promising; they have the potential to “disrupt” current treatment paradigms. And precedent shows that larger pharma companies routinely acquire early-stage development assets in this sector. Big pharma like Johnson & Johnson (NYSE: JNJ), Pfizer (NYSE: PFE), and Bristol Myers Squibb (NYSE: BMY) have essentially abandoned in-house development, instead acquiring promising assets like the ones in COEP’s arsenal to advance clinical ambitions.

In other words, the gap between Coeptis Therapeutics’ share price, intrinsic, and inherent potential may be too wide to ignore. Even after its recent bullish move, especially with expected updates proving that COEP is on an acquisition mission that creates shareholder value, considerable upside is likely in play. In fact, with analyst estimates modeling for a $5.00 share price, 152% higher than current, investment consideration in COEP, after appraising the sum of its parts, is more than timely; it’s justified.

 

 

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